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カタログ番号 | 製品名 | 別名 | ターゲット |
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T76096 | Purine nucleoside phosphorylase | ||
Purine Nucleoside Phosphorylase, an essential enzyme in purine metabolism, plays a critical role in the purine salvage pathway. Its deficiency impairs T cell function. With inorganic orthophosphate as a co-substrate, thi... | |||
T9727 | 2'-Fluoro-2'-Deoxyadenosine | Nucleoside Antimetabolite/Analog | |
2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors ex... | |||
T7782 | 3'-Deoxyguanosine | Others | |
3'-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors. | |||
T67822L | Ulodesine | BCX4208 | Endogenous Metabolite |
Ulodesine (BCX4208) is a purine nucleoside phosphorylase (PNP) inhibitor that inhibits PNP with an IC50 value of 2.293 nM/L. Ulodesine may be used to study hyperuricaemia. | |||
T12399 | Peldesine | BCX 34 | Nucleoside Antimetabolite/Analog , HIV Protease |
T70768 | MDL-74428 | ||
MDL-74428 is an inhibitor of purine nucleoside phosphorylase. | |||
TNU1023 | 7-Deaza-2’-deoxyadenosine | ||
Nucleoside Derivatives –7-Deaza-purine nucleosides; Drugs and Inhibitors; Purine nucleoside phosphorylase inhibitor | |||
T19148 | 5-Aza-7-deazaguanine | Others | |
5-Aza-7-deazaguanine is a substrate for E. coli purine nucleoside phosphorylase (wild-type/Ser90Ala mutant) in the synthesis of base-modified nucleosides. | |||
T14964 | CI 972 anhydrous | CI 972 (anhydrous) | Others |
CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent. | |||
T70939 | 8-Aminoinosine | ||
8-Aminoinosine is an endogenous 8-aminopurine that induces diuresis, natriuresis, and glucosuria by inhibiting purine nucleoside phosphorylase (PNPase). | |||
T78379 | 9-Deazaguanine | Others | |
9-Deazaguanine is a nucleoside analog that exhibits potent inhibitory activity against purine nucleoside phosphorylase (PNP) [1]. | |||
T15337 | Forodesine | BCX-1777,Immucillin-H | Others |
Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could i... | |||
T11313 | Forodesine hydrochloride | BCX-1777 hydrochloride,Immucillin-H hydrochloride | Others |
Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly... | |||
T60799 | Peldesine dihydrochloride | ||
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase (PNP), exhibiting IC50 values of 36 nM, 5 nM, and 32 nM against human, rat, and mous... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T1709 | 2'-Deoxyinosine | Guanine deoxyriboside,Deoxyinosine | Others , Endogenous Metabolite |
2'-Deoxyinosine (Guanine deoxyriboside) inhibits the growth of human colon-carcinoma cell lines and is associated with purine nucleoside phosphorylase (PNP) deficiency. | |||
T13539 | Allopurinol riboside | Others , Endogenous Metabolite , Parasite , Drug Metabolite | |
Allopurinol riboside is a metabolite of allopurinol and shows effective activities against parasites. |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-02279 | Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His) | Human | E. coli |
Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key en... |